Discovery of Genomic Characteristics and Selection Signatures in Korean Indigenous Goats Through Comparison of 10 Goat Breeds.

purebred develop their own genome characteristics to adapt to the local environment or culture for long periods of time. Most of them are not very productive in commercial terms, but they have the ability to survive in harsh environments or tolerate for a particular disease. adaptive characteristics they play an important role as the genetic material to improve commercial descent. As a step towards this goal, we analyzed the genomes of indigenous goats Korea within 10 descendants of goats.

We collected 136 individuals goat to order 46 new goat and employs 90 goats available to the public. Data whole genome consists of three purebred (Korea goat indigenous, goat indigenous Iran, and Morocco goat indigenous; n = 29, 18, 20), six offspring commercial (Saanen, Boer, Anglo-Nubian, British Alpine, Alpine, and Korea mulatto; n = 16, 11, 5, 5, 2, 13), and their ancestral species (Capra aegagrus; n = 17). We identified that the original goat indigenous goat Iran and Morocco have relatively similar genomic characteristics in broad categories genomic diversity but found that Korean native goats have unique genomic characteristics distinguished from nine other species. Through the analysis of the population, we confirmed that these characteristics have been generated from an isolated neighborhood near-with a strong genetic aberrations.

Korean native goats suffered a severe genetic bottleneck when entering the Korean Peninsula some 2,000 years ago, and has subsequently experienced a rare genetic interactions with other goat offspring. From the analysis of the selection and gene-set enrichment analysis, we disclose a selection signal for Salmonella infection and cardiomyopathy in the genome of the Korean indigenous goats. Adaptive characteristics are more identified with evidence-based genomik-. We found a selective sweep regions of the genome in the gene LBP and BPI (Salmonella infection) and TTN and ITGB6 gene (cardiomyopathy), among several candidate genes.

Our gift unique characteristics of genomics research and the selection signals typical of Korean indigenous goats is based on a broad comparison. Although the adaptive properties require further validation through experimental biology, our findings are expected to provide strategic direction for the future conservation of biological diversity and to contribute to other options for genomics-based breeding programs to improve the survival of Capra hircus.

Discovery of <em>Genomic</em> Characteristics and Selection Signatures in Korean Indigenous Goats Through Comparison of <em>10</em> Goat Breeds.
Discovery of Genomic Characteristics and Selection Signatures in Korean Indigenous Goats Through Comparison of 10 Goat Breeds.

influenza viruses that require 10 genome segments as antiviral therapy.

The influenza virus A (IAVs) genome encodes them in eight, negative sense RNA segments. During assembly of the virus, failure to package all of eight segments, or packaging segment mutates, making the resulting incomplete virions is infectious. It is known that the accumulation of damaged particles can limit the spread of disease by interfering with the virus entirely infectious particles.

Hepatitis C Virus Core (HCV Core)

MBS655272-5x01mg 5x0.1mg
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Hepatitis C (HCV) core

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Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (PE)

MBS6263056-01mL 0.1mL
EUR 950

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (PE)

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EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (PE)

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EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (PE)

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Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (AP)

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Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (AP)

MBS6260505-5x01mL 5x0.1mL
EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (AP)

MBS6260506-01mL 0.1mL
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Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (AP)

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Hepatitis C core antigen Antibody

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Hepatitis C core antigen Antibody

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Hepatitis C Core Antigen Antibody

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Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (HRP)

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EUR 950

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (HRP)

MBS6262545-5x01mL 5x0.1mL
EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (HRP)

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EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (HRP)

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Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (APC)

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Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (APC)

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EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (APC)

MBS6261017-01mL 0.1mL
EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (APC)

MBS6261017-5x01mL 5x0.1mL
EUR 4860

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (FITC)

MBS6262035-01mL 0.1mL
EUR 950

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (FITC)

MBS6262035-5x01mL 5x0.1mL
EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (FITC)

MBS6262036-01mL 0.1mL
EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (FITC)

MBS6262036-5x01mL 5x0.1mL
EUR 4860

Hepatitis C virus 2b core

MBS596135-1mg 1mg
EUR 425

Hepatitis C virus 2b core

MBS596135-2mg 2mg
EUR 700

Hepatitis C virus 2b core

MBS596135-5mg 5mg
EUR 1505

Hepatitis C virus 1b core

MBS596214-1mg 1mg
EUR 425

Hepatitis C virus 1b core

MBS596214-2mg 2mg
EUR 700

Hepatitis C virus 1b core

MBS596214-5mg 5mg
EUR 1505

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (Biotin)

MBS6261527-01mL 0.1mL
EUR 950

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (Biotin)

MBS6261527-5x01mL 5x0.1mL
EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (Biotin)

MBS6261528-01mL 0.1mL
EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (Biotin)

MBS6261528-5x01mL 5x0.1mL
EUR 4860

RECOMBINANT HEPATITIS C CORE ANTIGEN

MBS232046-01mg 0.1mg
EUR 720

RECOMBINANT HEPATITIS C CORE ANTIGEN

MBS232046-5x01mg 5x0.1mg
EUR 3075

Hepatitis C Virus Core, aa2-80 (HCV Core)

MBS644668-01mg 0.1mg
EUR 540

Hepatitis C Virus Core, aa2-80 (HCV Core)

MBS644668-5x01mg 5x0.1mg
EUR 2275

Hepatitis C (HCV) core, Antibody

GWB-16374C 0.1 mg Ask for price

Hepatitis C Virus Core, aa80-160 (HCV Core)

MBS641414-01mg 0.1mg
EUR 540

Hepatitis C Virus Core, aa80-160 (HCV Core)

MBS641414-5x01mg 5x0.1mg
EUR 2275

Hepatitis C Virus protein (Core)

30-AH69 1 mg
EUR 600
Description: Purified recombinant Hepatitis C Virus protein (Core)

Hepatitis C Virus protein (Core)

MBS538368-1mg 1mg
EUR 940

Hepatitis C Virus protein (Core)

MBS538368-5x1mg 5x1mg
EUR 4085

Hepatitis C virus core antigen

MBS596029-2mg 2mg
EUR 640

Hepatitis C virus core antigen

MBS596029-4mg 4mg
EUR 1115

Hepatitis C Virus antibody (core)

10-3139 500 ug
EUR 327
Description: Mouse Monoclonal Hepatitis C Virus antibody (core)

Hepatitis C Virus antibody (core)

10R-H107aX 100 ug
EUR 334
Description: Mouse monoclonal Hepatitis C Virus antibody (core)

Hepatitis C Virus antibody (core)

10R-H108a 100 ug
EUR 353
Description: Mouse monoclonal Hepatitis C Virus antibody (core)

Hepatitis C Virus antibody (core)

10R-H109a 100 ug
EUR 295
Description: Mouse monoclonal Hepatitis C Virus antibody (core)

Hepatitis C Virus antibody (core)

MBS530006-01mg 0.1mg
EUR 485

Hepatitis C Virus antibody (core)

MBS530006-5x01mg 5x0.1mg
EUR 2025

Hepatitis C Virus antibody (core)

MBS530468-01mg 0.1mg
EUR 460

Hepatitis C Virus antibody (core)

MBS530468-5x01mg 5x0.1mg
EUR 1920

Hepatitis C Virus antibody (core)

MBS530584-01mg 0.1mg
EUR 525

Hepatitis C Virus antibody (core)

MBS530584-5x01mg 5x0.1mg
EUR 2215

Hepatitis C Virus antibody (core)

MBS830609-05mg 0.5mg
EUR 445

Hepatitis C Virus antibody (core)

MBS830609-5x05mg 5x0.5mg
EUR 1855

MOUSE ANTI HEPATITIS C CORE ANTIGEN

MBS214534-01mg 0.1mg
EUR 590

MOUSE ANTI HEPATITIS C CORE ANTIGEN

MBS214534-5x01mg 5x0.1mg
EUR 2470

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 550)

MBS6264589-01mL 0.1mL
EUR 950

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 550)

MBS6264589-5x01mL 5x0.1mL
EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 550)

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EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 550)

MBS6264590-5x01mL 5x0.1mL
EUR 4860

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 650)

MBS6265100-01mL 0.1mL
EUR 950

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 650)

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EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 650)

MBS6265101-01mL 0.1mL
EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 650)

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EUR 4860

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 750)

MBS6265611-01mL 0.1mL
EUR 950

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 750)

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EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 750)

MBS6265612-01mL 0.1mL
EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 750)

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EUR 4860

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 405)

MBS6263567-01mL 0.1mL
EUR 950

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 405)

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EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 405)

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EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 405)

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EUR 4860

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 490)

MBS6264078-01mL 0.1mL
EUR 950

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 490)

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EUR 4135

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 490)

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EUR 1115

Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 490)

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EUR 4860

Hepatitis B Core Ag

GWB-9C0D7D 0.5 mg Ask for price

Hepatitis C Core Antigen (HCV) Protein

abx670101-100g 100 µg
EUR 487.5

Hepatitis C Core Antigen Antibody (FITC)

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Hepatitis B core (HBcAg)

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Hepatitis B Virus Core (HBV Core)

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Hepatitis B Core Antigen

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HEPATITIS B CORE ANTIGEN

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HEPATITIS B CORE ANTIGEN

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HEPATITIS B CORE ANTIGEN

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Hepatitis C (HCV) core (80-120), Antibody

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Human hepatitis C virus core (HCV -core ) ELISA Kit

SL2813Hu 96 Tests
EUR 468

Hepatitis B core particles

MBS328012-01mg 0.1mg
EUR 380

Hepatitis B core particles

MBS328012-5x01mg 5x0.1mg
EUR 1615

Hepatitis B core particles

MBS328013-01mg 0.1mg
EUR 435

Hepatitis B core particles

MBS328013-5x01mg 5x0.1mg
EUR 1865

Mouse Anti Hepatitis C Virus Core

MBS140205-05mg 0.5mg
EUR 440

Mouse Anti Hepatitis C Virus Core

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EUR 600

Mouse Anti Hepatitis C Virus Core

MBS140205-5x1mg 5x1mg
EUR 2375

Hepatitis C Virus Core antigen (HCV)

MBS6507662-1mL 1mL
EUR 590

Hepatitis C Virus Core antigen (HCV)

MBS6507662-5x1mL 5x1mL
EUR 2500

Hepatitis B Core, Recombinant (HBV Core, HBcAg)

MBS638143-01mg 0.1mg
EUR 540

Hepatitis B Core, Recombinant (HBV Core, HBcAg)

MBS638143-5x01mg 5x0.1mg
EUR 2275

Hepatitis B Core, Recombinant (HBV Core, HBcAg)

MBS636514-005mg 0.05mg
EUR 520

Hepatitis B Core, Recombinant (HBV Core, HBcAg)

MBS636514-01mg 0.1mg
EUR 770

Hepatitis B Core, Recombinant (HBV Core, HBcAg)

MBS636514-5x01mg 5x0.1mg
EUR 3245

Hepatitis C (HCV) core (1-80aa), Antibody

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Hepatitis C Virus Core Antigen (HCcAg)

REC31693-100 0.1
EUR 489.27
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.

Hepatitis C Virus Core Antigen (HCcAg)

REC31693-500 0.5
EUR 1469.11
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.

Virus Hepatitis C Core Antigen (HCV) Protein

abx670101-01mg 0.1 mg
EUR 678

Human Hepatitis C Virus core antibody

NBP2249 each
EUR 138
Description: ELISA,CLIA,

Human Hepatitis C Virus core antibody

NBP2250 each
EUR 138
Description: ELISA,CLIA,

Hepatitis C Virus Core 24 Recombinant

rAP-5285 Inquiry Ask for price

HEPATITIS B 320 CORE ANTIGEN

GWB-7DB073 0.05 mg Ask for price

Hepatitis B Core Ag 19kDa

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HBcAg (Hepatitis B Core) (PE)

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EUR 1060

HBcAg (Hepatitis B Core) (PE)

MBS6263028-5x01mL 5x0.1mL
EUR 4625

HBcAg (Hepatitis B Core) (AP)

MBS6260477-01mL 0.1mL
EUR 1060

HBcAg (Hepatitis B Core) (AP)

MBS6260477-5x01mL 5x0.1mL
EUR 4625

Hepatitis B virus core

MBS596065-1mg 1mg
EUR 425

Hepatitis B virus core

MBS596065-2mg 2mg
EUR 700

Hepatitis B virus core

MBS596065-5mg 5mg
EUR 1505

Hepatitis C Virus Core, Recombinant (HCV)

MBS635911-01mg 0.1mg
EUR 540

Hepatitis C Virus Core, Recombinant (HCV)

MBS635911-5x01mg 5x0.1mg
EUR 2275

HBcAg (Hepatitis B Core) (HRP)

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EUR 1060

HBcAg (Hepatitis B Core) (HRP)

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EUR 4625

HBcAg (Hepatitis B Core) (APC)

MBS6260988-01mL 0.1mL
EUR 1060

HBcAg (Hepatitis B Core) (APC)

MBS6260988-5x01mL 5x0.1mL
EUR 4625

Hepatitis C virus Core, NS3, NS4 (HCV)

MBS612174-1mL 1mL
EUR 575

Hepatitis C virus Core, NS3, NS4 (HCV)

MBS612174-5x1mL 5x1mL
EUR 2440

HBcAg (Hepatitis B Core) (FITC)

MBS6262007-01mL 0.1mL
EUR 1060

HBcAg (Hepatitis B Core) (FITC)

MBS6262007-5x01mL 5x0.1mL
EUR 4625

Hepatitis C Virus Core 22kDa Recombinant

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Hepatitis C Virus Core, Biotin Recombinant

rAP-5287 Inquiry Ask for price

Hepatitis B Core Antibody (ayw)

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Hepatitis B Core Antibody (ayw)

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Hepatitis B Core Antigen, ~80aa

MBS600706-01mg 0.1mg
EUR 700

Hepatitis B Core Antigen, ~80aa

MBS600706-5x01mg 5x0.1mg
EUR 3010

HBcAg (Hepatitis B Core) (Biotin)

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EUR 1060

HBcAg (Hepatitis B Core) (Biotin)

MBS6261499-5x01mL 5x0.1mL
EUR 4625

Hepatitis C virus core Recombinant Protein

53-324 0.01 mg
EUR 789.9
Description: Hepatitis C virus core Recombinant Protein

Hepatitis C virus core Recombinant Protein

53-327 0.01 mg
EUR 619.8
Description: Hepatitis C virus core Recombinant Protein

Hepatitis C virus core Recombinant Protein

53-328 0.01 mg
EUR 651.3
Description: Hepatitis C virus core Recombinant Protein

Hepatitis C virus core antigen (RECOMBINANT)

HCA-070-3 10ug
EUR 125

Hepatitis C virus core antigen (RECOMBINANT)

HCA-070-4 50ug
EUR 455

Hepatitis C Virus Core protein Recombinant

MBS553136-05mg 0.5mg
EUR 830

Hepatitis C Virus Core protein Recombinant

MBS553136-1mg 1mg
EUR 1315

Recombinant Hepatitis C Virus Core Protein

P1548-100 100 μg
EUR 296.4

Recombinant Hepatitis C Virus Core Protein

P1548-500 500 μg
EUR 1024.8

Hepatitis C Virus Core Antigen (HCV) (AP)

MBS6479968-01mL 0.1mL
EUR 865

Hepatitis C Virus Core Antigen (HCV) (AP)

MBS6479968-5x01mL 5x0.1mL
EUR 3750

Hepatitis C Virus Core Antigen (HCV) (PE)

MBS6479973-01mL 0.1mL
EUR 865

Hepatitis C Virus Core Antigen (HCV) (PE)

MBS6479973-5x01mL 5x0.1mL
EUR 3750

Hepatitis C Virus (HCV) Core Antigen (AP)

MBS6124676-01mL 0.1(mL
EUR 1285

Hepatitis C Virus (HCV) Core Antigen (AP)

MBS6124676-5x01mL 5x0.1mL
EUR 5640

Hepatitis C Virus (HCV) Core Antigen (AP)

MBS6124677-01mL 0.1(mL
EUR 1285

Hepatitis C Virus (HCV) Core Antigen (AP)

MBS6124677-5x01mL 5x0.1mL
EUR 5640

Hepatitis C Virus (HCV) Core Antigen (AP)

MBS6124678-01mL 0.1(mL
EUR 1285

Hepatitis C Virus (HCV) Core Antigen (AP)

MBS6124678-5x01mL 5x0.1mL
EUR 5640

Hepatitis C Virus Core Antigen (HCV) (AP)

MBS6124679-01mL 0.1(mL
EUR 1020

Hepatitis C Virus Core Antigen (HCV) (AP)

MBS6124679-5x01mL 5x0.1mL
EUR 4440

In order to capitalize on this phenomenon therapy, we define the viral packaging signal that agree to duplication and develop genetic platform that generates viral replication competent IAVs which takes up to two additional artificial genome segments for full infectivity. artificial genome segments modified and distributed by this approach is able to act as “bait” segment, when packaged by coinfecting wild-type virus, causing the production of non-infectious virus particles. Although IAVs requiring 10 genome segments for full infectivity able to replicate themselves and spread in vivo, modifications of their genome making them avirulent in mice.