purebred develop their own genome characteristics to adapt to the local environment or culture for long periods of time. Most of them are not very productive in commercial terms, but they have the ability to survive in harsh environments or tolerate for a particular disease. adaptive characteristics they play an important role as the genetic material to improve commercial descent. As a step towards this goal, we analyzed the genomes of indigenous goats Korea within 10 descendants of goats.
We collected 136 individuals goat to order 46 new goat and employs 90 goats available to the public. Data whole genome consists of three purebred (Korea goat indigenous, goat indigenous Iran, and Morocco goat indigenous; n = 29, 18, 20), six offspring commercial (Saanen, Boer, Anglo-Nubian, British Alpine, Alpine, and Korea mulatto; n = 16, 11, 5, 5, 2, 13 ), and their ancestral species (Capra aegagrus; n = 17). We identified that the original goat indigenous goat Iran and Morocco have relatively similar genomic characteristics in broad categories genomic diversity but found that Korean native goats have unique genomic characteristics distinguished from nine other species. Through the analysis of the population, we confirmed that these characteristics have been generated from an isolated neighborhood near-with a strong genetic aberrations.
Korean native goats suffered a severe genetic bottleneck when entering the Korean Peninsula some 2,000 years ago, and has subsequently experienced a rare genetic interactions with other goat offspring. From the analysis of the selection and gene-set enrichment analysis, we disclose a selection signal for Salmonella infection and cardiomyopathy in the genome of the Korean i ndigenous goats. Adaptive characteristics are more identified with evidence-based genomik-. We found a selective sweep regions of the genome in the gene LBP and BPI (Salmonella infection) and TTN and ITGB6 gene (cardiomyopathy), among several candidate genes.
Our gift unique characteristics of genomics research and the selection signals typical of Korean indigenous goats is based on a broad comparison. Although the adaptive properties require further validation through experimental biology, our findings are expected to provide strategic direction for the future conservation of biological diversity and to contribute to other options for genomics-based breeding programs to improve the survival of Capra hircus.
Discovery of Genomic Characteristics and Selection Signatures in Korean Indigenous Goats Through Comparison of 10 Goat Breeds.
influenza viruses that require 10 genome segments as antiviral therapy.
The influenza virus A (IAVs) genome encodes them in eight, negative sense RNA segments. During assembly of the virus, failure to package all of eight segments, or packaging segment mutates, making the resulting incomplete virions is infectious. It is known that the accumulation of damaged particles can limit the spread of disease by interfering with the virus entirely infectious particles.
Hepatitis C Virus Core (HCV Core)
MBS655272-5x01mg
MyBiosource
5x0.1mg
EUR 2700
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (PE)
MBS6263056-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (PE)
MBS6263056-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (PE)
MBS6263057-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (PE)
MBS6263057-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (AP)
MBS6260505-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (AP)
MBS6260505-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (AP)
MBS6260506-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (AP)
MBS6260506-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C core antigen Antibody
GWB-DAFEFB
GenWay Biotech
0.25 mg
Ask for price
Hepatitis C core antigen Antibody
GWB-C21C85
GenWay Biotech
0.25 mg
Ask for price
Hepatitis C Core Antigen Antibody
GWB-C575FD
GenWay Biotech
0.1 mg
Ask for price
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (HRP)
MBS6262545-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (HRP)
MBS6262545-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (HRP)
MBS6262546-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (HRP)
MBS6262546-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (APC)
MBS6261016-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (APC)
MBS6261016-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (APC)
MBS6261017-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (APC)
MBS6261017-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (FITC)
MBS6262035-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (FITC)
MBS6262035-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (FITC)
MBS6262036-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (FITC)
MBS6262036-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C virus 2b core
MBS596135-1mg
MyBiosource
1mg
EUR 425
Hepatitis C virus 2b core
MBS596135-2mg
MyBiosource
2mg
EUR 700
Hepatitis C virus 2b core
MBS596135-5mg
MyBiosource
5mg
EUR 1505
Hepatitis C virus 1b core
MBS596214-1mg
MyBiosource
1mg
EUR 425
Hepatitis C virus 1b core
MBS596214-2mg
MyBiosource
2mg
EUR 700
Hepatitis C virus 1b core
MBS596214-5mg
MyBiosource
5mg
EUR 1505
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (Biotin)
MBS6261527-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (Biotin)
MBS6261527-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (Biotin)
MBS6261528-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (Biotin)
MBS6261528-5x01mL
MyBiosource
5x0.1mL
EUR 4860
RECOMBINANT HEPATITIS C CORE ANTIGEN
MBS232046-01mg
MyBiosource
0.1mg
EUR 720
RECOMBINANT HEPATITIS C CORE ANTIGEN
MBS232046-5x01mg
MyBiosource
5x0.1mg
EUR 3075
Hepatitis C Virus Core, aa2-80 (HCV Core)
MBS644668-01mg
MyBiosource
0.1mg
EUR 540
Hepatitis C Virus Core, aa2-80 (HCV Core)
MBS644668-5x01mg
MyBiosource
5x0.1mg
EUR 2275
Hepatitis C (HCV) core, Antibody
GWB-16374C
GenWay Biotech
0.1 mg
Ask for price
Hepatitis C Virus Core, aa80-160 (HCV Core)
MBS641414-01mg
MyBiosource
0.1mg
EUR 540
Hepatitis C Virus Core, aa80-160 (HCV Core)
MBS641414-5x01mg
MyBiosource
5x0.1mg
EUR 2275
Hepatitis C Virus protein (Core)
30-AH69
Fitzgerald
1 mg
EUR 600
Description: Purified recombinant Hepatitis C Virus protein (Core)
Hepatitis C Virus protein (Core)
MBS538368-1mg
MyBiosource
1mg
EUR 940
Hepatitis C Virus protein (Core)
MBS538368-5x1mg
MyBiosource
5x1mg
EUR 4085
Hepatitis C virus core antigen
MBS596029-2mg
MyBiosource
2mg
EUR 640
Hepatitis C virus core antigen
MBS596029-4mg
MyBiosource
4mg
EUR 1115
Hepatitis C Virus antibody (core)
10-3139
Fitzgerald
500 ug
EUR 327
Description: Mouse Monoclonal Hepatitis C Virus antibody (core)
Hepatitis C Virus antibody (core)
10R-H107aX
Fitzgerald
100 ug
EUR 334
Description: Mouse monoclonal Hepatitis C Virus antibody (core)
Hepatitis C Virus antibody (core)
10R-H108a
Fitzgerald
100 ug
EUR 353
Description: Mouse monoclonal Hepatitis C Virus antibody (core)
Hepatitis C Virus antibody (core)
10R-H109a
Fitzgerald
100 ug
EUR 295
Description: Mouse monoclonal Hepatitis C Virus antibody (core)
Hepatitis C Virus antibody (core)
MBS530006-01mg
MyBiosource
0.1mg
EUR 485
Hepatitis C Virus antibody (core)
MBS530006-5x01mg
MyBiosource
5x0.1mg
EUR 2025
Hepatitis C Virus antibody (core)
MBS530468-01mg
MyBiosource
0.1mg
EUR 460
Hepatitis C Virus antibody (core)
MBS530468-5x01mg
MyBiosource
5x0.1mg
EUR 1920
Hepatitis C Virus antibody (core)
MBS530584-01mg
MyBiosource
0.1mg
EUR 525
Hepatitis C Virus antibody (core)
MBS530584-5x01mg
MyBiosource
5x0.1mg
EUR 2215
Hepatitis C Virus antibody (core)
MBS830609-05mg
MyBiosource
0.5mg
EUR 445
Hepatitis C Virus antibody (core)
MBS830609-5x05mg
MyBiosource
5x0.5mg
EUR 1855
MOUSE ANTI HEPATITIS C CORE ANTIGEN
MBS214534-01mg
MyBiosource
0.1mg
EUR 590
MOUSE ANTI HEPATITIS C CORE ANTIGEN
MBS214534-5x01mg
MyBiosource
5x0.1mg
EUR 2470
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 550)
MBS6264589-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 550)
MBS6264589-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 550)
MBS6264590-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 550)
MBS6264590-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 650)
MBS6265100-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 650)
MBS6265100-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 650)
MBS6265101-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 650)
MBS6265101-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 750)
MBS6265611-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 750)
MBS6265611-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 750)
MBS6265612-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 750)
MBS6265612-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 405)
MBS6263567-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 405)
MBS6263567-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 405)
MBS6263568-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 405)
MBS6263568-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 490)
MBS6264078-01mL
MyBiosource
0.1mL
EUR 950
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 490)
MBS6264078-5x01mL
MyBiosource
5x0.1mL
EUR 4135
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 490)
MBS6264079-01mL
MyBiosource
0.1mL
EUR 1115
Hepatitis C Virus (HCV, Hep C, Hepatitis C Virus Core) (MaxLight 490)
MBS6264079-5x01mL
MyBiosource
5x0.1mL
EUR 4860
Hepatitis C Core Antigen (HCV) Protein
abx670101-100g
Abbexa
100 µg
EUR 487.5
Hepatitis C Core Antigen Antibody (FITC)
GWB-534F41
GenWay Biotech
0.05 mg
Ask for price
Hepatitis B Virus Core (HBV Core)
GWB-2B5316
GenWay Biotech
1 mg
Ask for price
Hepatitis B Core Antigen
GWB-8C1766
GenWay Biotech
0.5 mg
Ask for price
HEPATITIS B CORE ANTIGEN
GWB-C24804
GenWay Biotech
0.1 mg
Ask for price
HEPATITIS B CORE ANTIGEN
GWB-79709C
GenWay Biotech
0.1 mg
Ask for price
HEPATITIS B CORE ANTIGEN
GWB-21D85D
GenWay Biotech
0.1 mg
Ask for price
Hepatitis C (HCV) core (80-120), Antibody
GWB-B02033
GenWay Biotech
0.1 mg
Ask for price
Human hepatitis C virus core (HCV -core ) ELISA Kit
SL2813Hu
Sunlong
96 Tests
EUR 468
Hepatitis B core particles
MBS328012-01mg
MyBiosource
0.1mg
EUR 380
Hepatitis B core particles
MBS328012-5x01mg
MyBiosource
5x0.1mg
EUR 1615
Hepatitis B core particles
MBS328013-01mg
MyBiosource
0.1mg
EUR 435
Hepatitis B core particles
MBS328013-5x01mg
MyBiosource
5x0.1mg
EUR 1865
Mouse Anti Hepatitis C Virus Core
MBS140205-05mg
MyBiosource
0.5mg
EUR 440
Mouse Anti Hepatitis C Virus Core
MBS140205-1mg
MyBiosource
1mg
EUR 600
Mouse Anti Hepatitis C Virus Core
MBS140205-5x1mg
MyBiosource
5x1mg
EUR 2375
Hepatitis C Virus Core antigen (HCV)
MBS6507662-1mL
MyBiosource
1mL
EUR 590
Hepatitis C Virus Core antigen (HCV)
MBS6507662-5x1mL
MyBiosource
5x1mL
EUR 2500
Hepatitis B Core, Recombinant (HBV Core, HBcAg)
MBS638143-01mg
MyBiosource
0.1mg
EUR 540
Hepatitis B Core, Recombinant (HBV Core, HBcAg)
MBS638143-5x01mg
MyBiosource
5x0.1mg
EUR 2275
Hepatitis B Core, Recombinant (HBV Core, HBcAg)
MBS636514-005mg
MyBiosource
0.05mg
EUR 520
Hepatitis B Core, Recombinant (HBV Core, HBcAg)
MBS636514-01mg
MyBiosource
0.1mg
EUR 770
Hepatitis B Core, Recombinant (HBV Core, HBcAg)
MBS636514-5x01mg
MyBiosource
5x0.1mg
EUR 3245
Hepatitis C (HCV) core (1-80aa), Antibody
GWB-8F0616
GenWay Biotech
0.1 mg
Ask for price
Hepatitis C Virus Core Antigen (HCcAg)
REC31693-100
The Native Antigen Company
0.1
EUR 489.27
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.
Hepatitis C Virus Core Antigen (HCcAg)
REC31693-500
The Native Antigen Company
0.5
EUR 1469.11
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.
Virus Hepatitis C Core Antigen (HCV) Protein
abx670101-01mg
Abbexa
0.1 mg
EUR 678
Human Hepatitis C Virus core antibody
NBP2249
Bioworld Biotech
each
EUR 138
Description: ELISA,CLIA,
Human Hepatitis C Virus core antibody
NBP2250
Bioworld Biotech
each
EUR 138
Description: ELISA,CLIA,
Hepatitis C Virus Core 24 Recombinant
rAP-5285
Angio Proteomie
Inquiry
Ask for price
HEPATITIS B 320 CORE ANTIGEN
GWB-7DB073
GenWay Biotech
0.05 mg
Ask for price
Hepatitis B Core Ag 19kDa
GWB-3C4809
GenWay Biotech
0.1 mg
Ask for price
HBcAg (Hepatitis B Core) (PE)
MBS6263028-01mL
MyBiosource
0.1mL
EUR 1060
HBcAg (Hepatitis B Core) (PE)
MBS6263028-5x01mL
MyBiosource
5x0.1mL
EUR 4625
HBcAg (Hepatitis B Core) (AP)
MBS6260477-01mL
MyBiosource
0.1mL
EUR 1060
HBcAg (Hepatitis B Core) (AP)
MBS6260477-5x01mL
MyBiosource
5x0.1mL
EUR 4625
Hepatitis B virus core
MBS596065-1mg
MyBiosource
1mg
EUR 425
Hepatitis B virus core
MBS596065-2mg
MyBiosource
2mg
EUR 700
Hepatitis B virus core
MBS596065-5mg
MyBiosource
5mg
EUR 1505
Hepatitis C Virus Core, Recombinant (HCV)
MBS635911-01mg
MyBiosource
0.1mg
EUR 540
Hepatitis C Virus Core, Recombinant (HCV)
MBS635911-5x01mg
MyBiosource
5x0.1mg
EUR 2275
HBcAg (Hepatitis B Core) (HRP)
MBS6262517-01mL
MyBiosource
0.1mL
EUR 1060
HBcAg (Hepatitis B Core) (HRP)
MBS6262517-5x01mL
MyBiosource
5x0.1mL
EUR 4625
HBcAg (Hepatitis B Core) (APC)
MBS6260988-01mL
MyBiosource
0.1mL
EUR 1060
HBcAg (Hepatitis B Core) (APC)
MBS6260988-5x01mL
MyBiosource
5x0.1mL
EUR 4625
Hepatitis C virus Core, NS3, NS4 (HCV)
MBS612174-1mL
MyBiosource
1mL
EUR 575
Hepatitis C virus Core, NS3, NS4 (HCV)
MBS612174-5x1mL
MyBiosource
5x1mL
EUR 2440
HBcAg (Hepatitis B Core) (FITC)
MBS6262007-01mL
MyBiosource
0.1mL
EUR 1060
HBcAg (Hepatitis B Core) (FITC)
MBS6262007-5x01mL
MyBiosource
5x0.1mL
EUR 4625
Hepatitis C Virus Core 22kDa Recombinant
rAP-5286
Angio Proteomie
Inquiry
Ask for price
Hepatitis C Virus Core, Biotin Recombinant
rAP-5287
Angio Proteomie
Inquiry
Ask for price
Hepatitis B Core Antibody (ayw)
GWB-3DB603
GenWay Biotech
0.1 mg
Ask for price
Hepatitis B Core Antibody (ayw)
GWB-148B36
GenWay Biotech
0.1 mg
Ask for price
Hepatitis B Core Antigen, ~80aa
MBS600706-01mg
MyBiosource
0.1mg
EUR 700
Hepatitis B Core Antigen, ~80aa
MBS600706-5x01mg
MyBiosource
5x0.1mg
EUR 3010
HBcAg (Hepatitis B Core) (Biotin)
MBS6261499-01mL
MyBiosource
0.1mL
EUR 1060
HBcAg (Hepatitis B Core) (Biotin)
MBS6261499-5x01mL
MyBiosource
5x0.1mL
EUR 4625
Hepatitis C virus core Recombinant Protein
53-324
ProSci
0.01 mg
EUR 789.9
Description: Hepatitis C virus core Recombinant Protein
Hepatitis C virus core Recombinant Protein
53-327
ProSci
0.01 mg
EUR 619.8
Description: Hepatitis C virus core Recombinant Protein
Hepatitis C virus core Recombinant Protein
53-328
ProSci
0.01 mg
EUR 651.3
Description: Hepatitis C virus core Recombinant Protein
Hepatitis C Virus Core protein Recombinant
MBS553136-05mg
MyBiosource
0.5mg
EUR 830
Hepatitis C Virus Core protein Recombinant
MBS553136-1mg
MyBiosource
1mg
EUR 1315
Recombinant Hepatitis C Virus Core Protein
P1548-100
Biovision
100 μg
EUR 296.4
Recombinant Hepatitis C Virus Core Protein
P1548-500
Biovision
500 μg
EUR 1024.8
Hepatitis C Virus Core Antigen (HCV) (AP)
MBS6479968-01mL
MyBiosource
0.1mL
EUR 865
Hepatitis C Virus Core Antigen (HCV) (AP)
MBS6479968-5x01mL
MyBiosource
5x0.1mL
EUR 3750
Hepatitis C Virus Core Antigen (HCV) (PE)
MBS6479973-01mL
MyBiosource
0.1mL
EUR 865
Hepatitis C Virus Core Antigen (HCV) (PE)
MBS6479973-5x01mL
MyBiosource
5x0.1mL
EUR 3750
Hepatitis C Virus (HCV) Core Antigen (AP)
MBS6124676-01mL
MyBiosource
0.1(mL
EUR 1285
Hepatitis C Virus (HCV) Core Antigen (AP)
MBS6124676-5x01mL
MyBiosource
5x0.1mL
EUR 5640
Hepatitis C Virus (HCV) Core Antigen (AP)
MBS6124677-01mL
MyBiosource
0.1(mL
EUR 1285
Hepatitis C Virus (HCV) Core Antigen (AP)
MBS6124677-5x01mL
MyBiosource
5x0.1mL
EUR 5640
Hepatitis C Virus (HCV) Core Antigen (AP)
MBS6124678-01mL
MyBiosource
0.1(mL
EUR 1285
Hepatitis C Virus (HCV) Core Antigen (AP)
MBS6124678-5x01mL
MyBiosource
5x0.1mL
EUR 5640
Hepatitis C Virus Core Antigen (HCV) (AP)
MBS6124679-01mL
MyBiosource
0.1(mL
EUR 1020
Hepatitis C Virus Core Antigen (HCV) (AP)
MBS6124679-5x01mL
MyBiosource
5x0.1mL
EUR 4440
In order to capitalize on this phenomenon therapy, we define the viral packaging signal that agree to duplication and develop genetic platform that generates viral replication competent IAVs which takes up to two additional artificial genome segments for full infectivity. artificial genome segments modified and distributed by this approach is able to act as “bait” segment, when packaged by coinfecting wild-type virus, causing the production of non-infectious virus particles. Although IAVs requiring 10 genome segments for full infectivity able to replicate themselves and spread in vivo, modifications of their genome making them avirulent in mice.